Manchester United began their campaign with a 1–0 win at home to Tottenham Hotspur on 8 August 2015, with an own goal from Kyle Walker proving the difference between the two teams.United then went top of the league for the first time since August 2013 with another 1–0 win over Aston Villa at Villa Park the following Friday; Adnan Januzaj's goal in the 29th minute was his first since April 2014.The game had moved to Friday for policing reasons due to an English Defence League march in nearby Walsall the following day, a decision which also gave United an extra day to prepare for their Champions League play-off against Club Brugge. United kept a third clean sheet in a row at home to Newcastle United on 22 August, but the forwards were unable to find the net and the match finished as a goalless draw. In the final fixture before the first international break, United conceded their first goals of the season as they lost 2–1 to Swansea City; after going ahead early in the second half through Juan Mata, they conceded twice in five minutes just after the hour mark, first to a header from André Ayew, who then provided the assist for Bafétimbi Gomis.
Following the international break, Manchester United returned to action with a home match against Liverpool. The first half was goalless, but goals from Daley Blind and Ander Herrera gave them the lead going into the last 10 minutes. Christian Benteke then pulled one back for Liverpool with a bicycle kick, before deadline day signing Anthony Martial scored a debut goal to seal a 3–1 win. Martial continued his scoring when United won 3–2 away to Southampton. Graziano Pellè first gave Southampton the lead before Martial scored a brace; the first goal before halftime and the second goal after. United also added a third goal from Juan Mata before Pellè could score his second and the final goal of the match. On 26 September, United went on top of the league for the first time in over two years after beating Sunderland at home. Memphis Depayopened the scoring in first half stoppage time and Rooney scored 40 seconds into the second half - ending his longest barren spell in the Premier league after not scoring in 11 matches - before Mata scored the final goal in the last minute of regular time to secure a 3–0 win. On 4 October, in the last match before a new international break, United suffered a 3–0 loss against Arsenal. Arsenal drew first blood through an Alexis Sánchez goal in the 6th minute before Mesut Özil added to the score barely 74 seconds later. Sánchez completed his brace in the 19th minute to condemn United to their second loss in the league this season, which made United drop to third in the league standings, behind Arsenal on goal difference.
|Pos||Team||Pld||W||D||L||GF||GA||GD||Pts||Qualification or relegation|
|1||Manchester City||8||6||0||2||19||7||+12||18||Qualification to Champions League group stage|
|4||Crystal Palace||8||5||0||3||11||7||+4||15||Qualification to Champions League play-off round|
|5||Leicester City||8||4||3||1||17||15||+2||15||Qualification to Europa League group stage|